Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469675 | 0.84 | CA12 (0.55) | MAPK1LMNARAB9ATSHRHTT | |
| SCHEMBL6166429 | 0.84 | MAPT (0.48) | MAPTALDH1A1MAPK1HSD17B2LMNA | |
| SCHEMBL7684319 | 0.83 | MAPT (0.77) | MAPTALDH1A1MAPK1HSD17B2LMNA | |
| SCHEMBL27574703 | 0.81 | CA12 (0.45) | MAPTLMNARAB9ANPC1HTT | |
| SCHEMBL6168127 | 0.80 | KDM4E (0.45) | MAPTALDH1A1MAPK1TSHRALOX15 | |
| SCHEMBL11341115 | 0.79 | MAPT (0.61) | MAPTALDH1A1MAPK1HSD17B2LMNA | |
| SCHEMBL30506315 | 0.77 | HSD17B2 (0.76) | MAPTALDH1A1MAPK1HSD17B2LMNA | |
| SCHEMBL1660365 | 0.77 | HSD17B2 (0.76) | MAPTALDH1A1MAPK1HSD17B2LMNA | |
| SCHEMBL6166515 | 0.77 | MAPT (0.49) | MAPTALDH1A1LMNANPC1SMN1; SMN2 | |
| SCHEMBL6638697 | 0.74 | SLC6A2 (0.44) | MAPTALDH1A1MAPK1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592423-A2 | COMBINATION THERAPY OF ZD6474 WITH 5-FU AND/OR CPT-11 | Astrazeneca AB (SE) | 2005-11-09 | — | — | EP | disclosed |
| EP-1534287-A1 | COMBINATION OF ZD6474, AN INHIBITOR OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, WITH RADIOTHERAPY IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004071397-A2 | COMBINATION THERAPY OF ZD6474 WITH 5-FU OR/AND CPT-11 | ASTRAZENECA AB (SE) | 2004-08-26 | — | — | WO | disclosed |
| EP-1446124-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | AstraZeneca AB (SE) | 2004-08-18 | — | — | EP | disclosed |
| WO-2004014383-A1 | COMBINATION OF ZD6474, AN INHIBITOR OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, WITH RADIOTHERAPY IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |
| WO-2003039551-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |
| EP-1244647-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2001032651-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |