Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371991 | 0.83 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL446532 | 0.81 | JAK2 (0.36) | SLC6A2SLC6A4SLC6A3GAAJAK2 | |
| SCHEMBL8791343 | 0.80 | ALOX15 (0.41) | SLC6A2SLC6A4SLC6A3CYP2D6MAPK1 | |
| SCHEMBL4929501 | 0.80 | SLC6A4 (0.41) | SLC6A2SLC6A4SLC6A3GAATSHR | |
| SCHEMBL7469675 | 0.79 | CA12 (0.55) | SLC6A2SLC6A4SLC6A3CYP2D6TSHR | |
| SCHEMBL2371617 | 0.78 | MAPT (0.55) | GAAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL15650817 | 0.78 | PDE4B (0.48) | SLC6A2SLC6A4SLC6A3GAAMAPT | |
| SCHEMBL444816 | 0.78 | SLC6A4 (0.35) | SLC6A2SLC6A4SLC6A3HTR2CJAK2 | |
| SCHEMBL6619157 | 0.78 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CYP2D6KDM4E | |
| SCHEMBL2031773 | 0.75 | ALDH1A1 (0.45) | SLC6A2SLC6A4SLC6A3HTR2CJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |