Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | TPMT | P51580 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222829 | 0.84 | MAPT (0.56) | TSHRHTTLMNAMAPK1RAB9A | |
| SCHEMBL6168405 | 0.82 | CA12 (0.46) | CA12CA1CA2CA4CA6 | |
| SCHEMBL1015345 | 0.80 | CA12 (0.73) | CA12CA1CA2CA4CA6 | |
| SCHEMBL6638697 | 0.79 | SLC6A2 (0.44) | TSHRHTTMAPK1SLC6A2SLC6A4 | |
| SCHEMBL1554712 | 0.76 | CA12 (0.71) | CA12CA1CA2CA4CA6 | |
| SCHEMBL6619157 | 0.76 | SLC6A2 (0.41) | CA12CA1CA2CA9TSHR | |
| SCHEMBL20428527 | 0.74 | CA12 (0.55) | CA12CA1CA2CA4CA6 | |
| SCHEMBL3924278 | 0.74 | CA12 (0.73) | CA12CA1CA2CA4CA6 | |
| SCHEMBL8948042 | 0.74 | MEN1 (0.58) | CA12CA1CA2CA4CA6 | |
| Veratric Acid SCHEMBL976032 | 0.73 | CA12 (1.00) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |