Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122591 | 0.87 | ESR1 (0.45) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL2122918 | 0.85 | SLC18A2 (0.36) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL5552130 | 0.84 | DRD1 (0.44) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL5242671 | 0.82 | STS (0.37) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL2124647 | 0.81 | ESR1 (0.44) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL5556509 | 0.81 | ADRB3 (0.37) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL4637685 | 0.78 | NR1H2 (0.39) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL6228809 | 0.78 | GRIN1 (0.40) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL5669989 | 0.77 | ESR1 (0.38) | SLC18A2MAPK1HSD17B10KDM4EABCB11 | |
| SCHEMBL6223637 | 0.77 | MAOA (0.34) | MAPK1HSD17B10KDM4EMAPTMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572215-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056369-A1 | BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |