Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165139 | 0.83 | GRIN1 (0.54) | GRIN1GRIN2BHRH3GHSR | |
| SCHEMBL6228806 | 0.83 | GRIN1 (0.40) | GRIN1GRIN2BMTNR1BFFAR1GPR183 | |
| SCHEMBL6223641 | 0.78 | SLC18A2 (0.36) | MAPTKDM4EABCB11ALDH1A1POLB | |
| SCHEMBL6225071 | 0.76 | HRH3 (0.42) | MTNR1BHRH3MAPTKDM4EABCB11 | |
| SCHEMBL2124647 | 0.75 | ESR1 (0.44) | GRIN1GRIN2BMAPTKDM4EABCB11 | |
| SCHEMBL5670085 | 0.75 | TMEM97 (0.56) | HRH3HTR1AADRA2AHTR2B | |
| SCHEMBL5170176 | 0.73 | SLC18A2 (0.36) | MTNR1BMAPTKDM4EABCB11ALDH1A1 | |
| SCHEMBL5670231 | 0.73 | LNPEP (0.49) | HRH3HTR1AADRA2AHTR2BGHSR | |
| SCHEMBL5170187 | 0.72 | SLC18A2 (0.36) | MTNR1BMAPTKDM4EABCB11ALDH1A1 | |
| SCHEMBL5551732 | 0.72 | MTNR1B (0.50) | GRIN1GRIN2BMTNR1BMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572215-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056369-A1 | BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |