Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449135 | 0.86 | POLB (0.63) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL7339506 | 0.85 | LMNA (0.61) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL184778 | 0.85 | LMNA (0.61) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL27993011 | 0.84 | GAA (0.62) | SMN1; SMN2POLBGAAATMTHRB | |
| SCHEMBL30510136 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL9405372 | 0.84 | POLB (0.73) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL856302 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL30297472 | 0.83 | LMNA (0.59) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL5156110 | 0.83 | LMNA (0.59) | SMN1; SMN2LMNAPOLBGAAATM | |
| SCHEMBL29780696 | 0.83 | LMNA (0.54) | SMN1; SMN2LMNAPOLBATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126840-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |
| EP-4100008-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | The Rockefeller University (US) | 2022-12-14 | — | — | EP | disclosed |
| EP-3986887-A1 | TARGETED PROTEIN DEGRADATION OF PARP14 FOR USE IN THERAPY | Ribon Therapeutics Inc. (US) | 2022-04-27 | — | — | EP | disclosed |
| EP-1500657-A1 | Substituted pyrazoles as P38 kinase inhibitors | G.D. Searle LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
| US-5939436-A | Five-membered heteroaromatic compounds as dopamine receptor subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 1999-08-17 | — | — | US | disclosed |
| WO-1996021660-A1 | FIVE-MEMBERED HETEROAROMATIC COMPOUNDS AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1996-07-18 | — | — | WO | disclosed |