SCHEMBL622393

SCHEMBL622393

C/C(C(=O)O)=C(/CC(C)(C)C)N(C)C

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.31
CHRM1 P11229 1/20 0.31
TBXA2R P21731 1/20 0.31
ADRA1A P35348 1/20 0.31
CYP2D6 P10635 1/20 0.30
TSHR P16473 1/20 0.30
CYP2C19 P33261 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL622396 1.00 HMGCR (0.31) HMGCRCHRM1TBXA2RADRA1ACYP2D6
SCHEMBL5693456 0.81
SCHEMBL5965051 0.81
SCHEMBL622827 0.79 LMNA (0.32)
SCHEMBL622824 0.79 LMNA (0.32)
SCHEMBL8679666 0.77 HMGCR (0.30) HMGCRCHRM1TBXA2RADRA1A
Chloromethane SCHEMBL219837 0.76 ALDH1A1 (0.33) TSHR
SCHEMBL44909 0.75 ALDH1A1 (0.36)
SCHEMBL109778 0.75 ALDH1A1 (0.36)
Chloromethane SCHEMBL9414315 0.74 ALDH1A1 (0.32) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2568967-B2 PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROMORPHONE AND NALOXONE EURO CELTIQUE SA (LU) 2022-07-27 EP disclosed
US-20190224130-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROMORPHONE AND NALOXONE PURDUE PHARMA (CA) 2019-07-25 US disclosed
EP-3505162-A1 USE OF BINDERS FOR MANUFACTURING STORAGE STABLE FORMULATIONS Euro-Celtique S.A. (LU) 2019-07-03 EP disclosed
EP-2568967-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROMORPHONE AND NALOXONE EURO CELTIQUE SA (LU) 2018-10-24 EP disclosed
EP-2603205-B1 USE OF BINDERS FOR MANUFACTURING STORAGE STABLE FORMULATIONS EURO CELTIQUE SA (LU) 2018-10-03 EP disclosed
US-9993433-B2 Manufacturing of active-free granules and tablets comprising the same EURO-CELTIQUE S.A. (LU) 2018-06-12 US disclosed
US-9901540-B2 Combination of active loaded granules with additional actives EURO-CELTIQUE S.A. (LU) 2018-02-27 US disclosed
EP-2568968-B1 Manufacturing of active-free granules and tablets comprising the same EURO CELTIQUE SA (LU) 2017-07-12 EP disclosed
US-9700508-B2 Pharmaceutical compositions comprising hydromorphone and naloxone EURO-CELTIQUE S.A. (GB) 2017-07-11 US disclosed
US-20170182031-A1 REDUCING DRUG LIKING IN A SUBJECT PURDUE PHARMA (CA) 2017-06-29 US disclosed
EP-2568967-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROMORPHONE AND NALOXONE Euro-Celtique S.A. (LU) 2013-03-20 EP disclosed
WO-2012020097-A2 USE OF BINDERS FOR MANUFACTURING STORAGE STABLE FORMULATIONS EURO-CELTIQUE S.A. (LU) 2012-02-16 WO disclosed
WO-2011141490-A1 COMBINATION OF ACTIVE LOADED GRANULES WITH ADDITIONAL ACTIVES EURO-CELTIQUE S.A. (LU) 2011-11-17 WO disclosed
WO-2011141489-A1 MANUFACTURING OF ACTIVE-FREE GRANULES AND TABLETS COMPRISING THE SAME EURO-CELTIQUE S.A. (LU) 2011-11-17 WO disclosed
WO-2011141488-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROMORPHONE AND NALOXONE EURO-CELTIQUE S.A. (LU) 2011-11-17 WO disclosed
EP-1487882-B1 BASE POLYMER OBTAINED BY HYDROGENATION STOCKHAUSEN CHEM FAB GMBH (DE) 2006-05-24 EP disclosed
US-20050215756-A1 Basic polymer obtained by hydrogenation STOCKHAUSEN GMBH (DE) 2005-09-29 US disclosed
EP-1487882-A1 BASE POLYMER OBTAINED BY HYDROGENATION Stockhausen GmbH (DE) 2004-12-22 EP disclosed
WO-2003080682-A1 BASE POLYMER OBTAINED BY HYDROGENATION STOCKHAUSEN GMBH (DE) 2003-10-02 WO disclosed
EP-0058765-B1 COATING SOLUBLE OR SWELLABLE IN GASTRIC JUICE, AND ITS USE IN A PROCESS FOR COATING PHARMACEUTICAL PREPARATIONS RÖHM GMBH (DE) 1985-02-20 EP disclosed