Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7831830 | 0.91 | SLC2A1 (0.39) | SLC2A1KCNH2CCR8KMT2A | |
| Oxalic Acid SCHEMBL6222732 | 0.88 | SLC2A1 (0.39) | SLC2A1CHRM3KCNH2 | |
| Oxalic Acid SCHEMBL6223377 | 0.86 | CCR8 (0.47) | SLC2A1CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL6223378 | 0.86 | CCR8 (0.47) | SLC2A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6221361 | 0.85 | KCNH2 (0.40) | SLC2A1KCNH2CCR8 | |
| SCHEMBL6221359 | 0.80 | KCNH2 (0.38) | KCNH2 | |
| Oxalic Acid SCHEMBL7840279 | 0.80 | CHRM2 (0.38) | SLC2A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6220896 | 0.78 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL6214270 | 0.77 | KCNH2 (0.51) | KCNH2 | |
| Oxalic Acid SCHEMBL6215855 | 0.77 | SLC2A1 (0.40) | SLC2A1KCNH2CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121355-B1 | QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2005-12-14 | — | — | EP | disclosed |
| US-6602882-B1 | Quinoline derivatives and their use as antibacterial agents | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-08-05 | — | — | US | disclosed |
| EP-1144404-A1 | PIPERIDINYLQUINOLINES AS PROTEIN TYROSINE KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043383-A1 | PIPERIDINYLQUINOLINES AS PROTEIN TYROSINE KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-07-27 | — | — | WO | disclosed |