Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220857 | 0.83 | KCNH2 (0.41) | KCNH2MAPT | |
| SCHEMBL6220846 | 0.83 | KCNH2 (0.41) | KCNH2MAPT | |
| SCHEMBL6220851 | 0.83 | KCNH2 (0.41) | KCNH2MAPT | |
| SCHEMBL6221359 | 0.80 | KCNH2 (0.38) | KCNH2MAPTPIK3CA | |
| Oxalic Acid SCHEMBL6224062 | 0.78 | SLC2A1 (0.38) | KCNH2 | |
| SCHEMBL633958 | 0.71 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL5512410 | 0.71 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5511934 | 0.71 | ROCK2 (0.46) | KCNH2BRD4 | |
| SCHEMBL12837408 | 0.70 | MAPT (0.51) | KCNH2MAPTPKM | |
| Oxalic Acid SCHEMBL7831830 | 0.69 | SLC2A1 (0.39) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121355-B1 | QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2005-12-14 | — | — | EP | disclosed |
| US-6602882-B1 | Quinoline derivatives and their use as antibacterial agents | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-08-05 | — | — | US | disclosed |
| EP-1121355-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021952-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-04-20 | — | — | WO | disclosed |