Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.67 |
| ▸ | PKLR | P30613 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GCK | P35557 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266849 | 1.00 | PKM (0.67) | PKMPKLRPOLBMAPK1LMNA | |
| SCHEMBL2856804 | 0.94 | APOBEC3A (0.67) | PKMPKLRPOLBMAPK1LMNA | |
| SCHEMBL10860773 | 0.92 | PKM (0.77) | PKMPKLRLMNAHTTTSHR | |
| SCHEMBL396589 | 0.85 | ALDH1A1 (0.69) | PKMPKLRLMNAHTTTSHR | |
| SCHEMBL264656 | 0.83 | ALDH1A1 (0.67) | PKMPKLRLMNAHTTTSHR | |
| SCHEMBL14093748 | 0.83 | PKM (0.62) | PKMPKLRLMNATSHRKDM4E | |
| SCHEMBL28871030 | 0.83 | POLB (0.59) | PKMPOLBMAPK1LMNAHTT | |
| SCHEMBL13421456 | 0.83 | POLB (0.58) | POLBLMNAHTTAPOBEC3AAPOBEC3G | |
| SCHEMBL14263406 | 0.82 | POLB (0.67) | PKMPOLBMAPK1LMNAHTT | |
| SCHEMBL4384015 | 0.81 | ALDH1A1 (0.68) | PKMPKLRPOLBLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |