Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 5/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | RARA | P10276 | 4/20 | 0.34 |
| ▸ | RARB | P10826 | 4/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | RXRB | P28702 | 3/20 | 0.33 |
| ▸ | RXRG | P48443 | 3/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023001 | 1.00 | KDM1A (0.47) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7025785 | 1.00 | KDM1A (0.47) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7022663 | 0.85 | RARB (0.39) | RARARARBRXRARXRBRXRG | |
| SCHEMBL6224084 | 0.85 | RARB (0.39) | RARARARBRXRARXRBRXRG | |
| SCHEMBL6224309 | 0.84 | KDM1A (0.47) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6223471 | 0.77 | RXRA (0.63) | KDM1ARARARARBRXRARXRB | |
| SCHEMBL21750795 | 0.77 | KDM1A (0.53) | KDM1ARARARARBRARGESR2 | |
| SCHEMBL15616678 | 0.77 | KDM1A (0.50) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6225050 | 0.77 | KDM1A (0.50) | KDM1AESR2 | |
| SCHEMBL6221173 | 0.76 | RXRA (0.39) | RARARARBRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354878-B1 | Tetrahydroquinoline derivatives having selective activity for retinoid x receptors | ALLERGAN INC (US) | 2005-11-23 | — | — | EP | disclosed |
| EP-1354878-A2 | Tetrahydroquinoline derivatives having selective activity for retinoid x receptors | Allergan, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1117648-B1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | ALLERGAN INC (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1117648-A1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | Allergan Sales, Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020397-A1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | ALLERGAN SALES, INC. (US) | 2000-04-13 | — | — | WO | disclosed |
| US-6048873-A | SKIN DISORDERS | ALLERGAN SALES, INC. (US) | 2000-04-11 | — | — | US | disclosed |