Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | LSS | P48449 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221960 | 0.99 | MCHR1 (0.57) | MCHR1CHRM1HTR2ACYP2D6LSS | |
| SCHEMBL6224507 | 0.92 | MCHR1 (0.48) | MCHR1CHRM1HTR2ACYP2D6LSS | |
| SCHEMBL6227023 | 0.91 | MCHR1 (0.46) | MCHR1CHRM1HTR2ACYP2D6LSS | |
| SCHEMBL6223473 | 0.91 | MCHR1 (0.46) | MCHR1CHRM1HTR2ACYP2D6TDP1 | |
| SCHEMBL6222416 | 0.91 | MCHR1 (0.57) | MCHR1CHRM1HTR2ACYP2D6FAAH | |
| SCHEMBL6225400 | 0.89 | MAPT (0.49) | MCHR1CHRM1HTR2ACYP2D6 | |
| SCHEMBL6225286 | 0.89 | MCHR1 (0.44) | MCHR1CHRM1HTR2ACYP2D6LSS | |
| SCHEMBL6223851 | 0.89 | MCHR1 (0.48) | MCHR1CHRM1HTR2ACYP2D6 | |
| SCHEMBL6225433 | 0.88 | FAAH (0.50) | MCHR1CHRM1HTR2ACYP2D6FAAH | |
| SCHEMBL6228504 | 0.87 | FAAH (0.49) | MCHR1CHRM1HTR2ACYP2D6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534689-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004024702-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-25 | — | — | WO | disclosed |