SCHEMBL6225433

SCHEMBL6225433

O=C(NCCc1ccc(CN2CCN(c3ccccc3)CC2)cc1)Oc1ccc(-c2ccc(Cl)cc2)cc1[N+](=O)[O-]

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 3/20 0.50
BCHE P06276 2/20 0.50
ACHE P22303 2/20 0.50
MCHR1 Q99705 5/20 0.44
HTR2A P28223 3/20 0.44
CHRM1 P11229 2/20 0.44
CYP2D6 P10635 1/20 0.44
MAPK1 P28482 3/20 0.44
TSHR P16473 1/20 0.44
DRD3 P35462 2/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPT P10636 3/20 0.43
LMNA P02545 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HTR1A P08908 1/20 0.43
DRD2 P14416 1/20 0.43
USP2 O75604 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TAAR1 Q96RJ0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6221960 0.89 MCHR1 (0.57) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6224697 0.88 MCHR1 (0.57) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6224439 0.87 FAAH (0.47) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6228504 0.87 FAAH (0.49) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6225461 0.86 MCHR1 (0.47) FAAHMCHR1HTR2ACHRM1CYP2D6
SCHEMBL6704624 0.86 NPC1 (0.61) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6224507 0.84 MCHR1 (0.48) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6225469 0.82 ACHE (0.46) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6222416 0.81 MCHR1 (0.57) FAAHBCHEACHEMCHR1HTR2A
SCHEMBL6227023 0.81 MCHR1 (0.46) FAAHBCHEACHEMCHR1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534689-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-06-01 EP disclosed
WO-2004024702-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-03-25 WO disclosed