Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23512615 | 0.85 | EGLN1 (0.44) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL8150967 | 0.85 | ALDH1A1 (0.60) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL14651299 | 0.84 | P4HTM (0.47) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL286868 | 0.84 | KDM4E (0.69) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL2642695 | 0.82 | P4HTM (0.46) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL17682180 | 0.82 | P4HTM (0.46) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL9249692 | 0.82 | P4HTM (0.46) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL5755133 | 0.82 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL30024604 | 0.82 | P4HTM (0.46) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL7995510 | 0.82 | P4HTM (0.46) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356387-B1 | ANTIMICROBIAL POLYMYXIN DERIVATIVE COMPOUNDS | UNIV MONASH (AU) | 2024-06-26 | — | — | EP | disclosed |
| WO-2022272106-A1 | CDK2 INHIBITORS AND METHODS OF USING THE SAME | CEDILLA THERAPEUTICS, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| US-11225505-B2 | Antimicrobial polymyxin derivative compounds | MONASH UNIVERSITY (AU) | 2022-01-18 | — | — | US | disclosed |
| EP-2603507-B1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEV CO LLC (US) | 2016-06-29 | — | — | EP | disclosed |
| EP-2603507-B1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEV CO LLC (US) | 2016-06-29 | — | — | EP | disclosed |
| US-8993773-B2 | Process to prepare pioglitazone via several novel intermediates | CADILA HEALTHCARE LIMITED (IN) | 2015-03-31 | — | — | US | disclosed |
| US-8946435-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946435-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946435-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140378687-A1 | Synthesis for Thiazolidinedione Compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC | 2014-12-25 | — | — | US | disclosed |
| US-7465801-B2 | Process to prepare pioglitazone via several novel intermediates | CADILA HEALTHCARE LIMITED (IN) | 2008-12-16 | — | — | US | disclosed |
| US-20080300282-A1 | Novel process to prepare pioglitazone via several novel intermediates | CADILA HEALTHCARE LIMITED (IN) | 2008-12-04 | — | — | US | disclosed |
| US-20080004446-A1 | Novel process to prepare pioglitazone via several novel intermediates | CADILA HEALTHCARE LIMITED (IN) | 2008-01-03 | — | — | US | disclosed |
| US-20070219210-A1 | Amidopyrazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1521753-B1 | A PROCESS TO PREPARE PIOGLITAZONE VIA SEVERAL INTERMEDIATES. | CADILA HEALTHCARE LTD (IN) | 2007-09-05 | — | — | EP | disclosed |
| EP-1698626-A1 | AMIDOPYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-09-06 | — | — | EP | disclosed |
| US-20060167061-A1 | Novel process to prepare pioglitazone via several novel intermediates | CADILA HEALTHCARE LIMITED | 2006-07-27 | — | — | US | disclosed |
| EP-1521753-A2 | A PROCESS TO PREPARE PIOGLITAZONE VIA SEVERAL INTERMEDIATES. | CADILA HEALTHCARE LTD. (IN) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004007490-A2 | A PROCESS TO PREPARE PIOGLITAZONE VIA SEVERAL INTERMEDIATES. | CADILA HEALTHCARE LIMITED (IN) | 2004-01-22 | — | — | WO | disclosed |
| JP-2000226370-A | PRODUCTION OF 2-ACYLPYRIDINE DERIVATIVE | KURARAY CO LTD | 2000-08-15 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11225505-B2 | Antimicrobial polymyxin derivative compounds | VIP, PNKP, PEPD | L3MBTL1 1643/4885ALDH1A1 4859/4885KDM4E 4142/4885 |
| US-20070219210-A1 | Amidopyrazole Derivative | PTGER1, PTGS1, PTGER2 | L3MBTL1 3071/4885ALDH1A1 171/4885KDM4E 2495/4885 |
| US-20080004446-A1 | Novel process to prepare pioglitazone via several novel intermediates | PPARD, PPARG, PPARA | L3MBTL1 4871/4885ALDH1A1 742/4885KDM4E 4174/4885 |
| US-20140378687-A1 | Synthesis for Thiazolidinedione Compounds | PPARD, PPARG, PPARA | L3MBTL1 3279/4885ALDH1A1 494/4885KDM4E 1400/4885 |
| US-20080300282-A1 | Novel process to prepare pioglitazone via several novel intermediates | PPARD, PPARG, PPARA | L3MBTL1 4864/4885ALDH1A1 1084/4885KDM4E 3954/4885 |
| US-20060167061-A1 | Novel process to prepare pioglitazone via several novel intermediates | PPARD, PPARG, PPARA | L3MBTL1 4864/4885ALDH1A1 1084/4885KDM4E 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.