Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.53 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984552 | 0.86 | HDAC6 (0.55) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL226465 | 0.84 | UBE2T (0.70) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| Bromide SCHEMBL7601035 | 0.82 | UBE2T (0.68) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL9306082 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL7600826 | 0.81 | UBE2T (0.61) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| Fluoride SCHEMBL7600822 | 0.81 | UBE2T (0.66) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL20651365 | 0.80 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL7219825 | 0.78 | DYRK1A (0.45) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL4583713 | 0.78 | LOXL2 (0.65) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T | |
| SCHEMBL8461410 | 0.78 | LOXL2 (0.47) | SMN1; SMN2NPC1RAB9AKMT2AUBE2T |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003076443-A9 | SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY | BANYU PHARMA CO LTD (JP) | 2005-01-20 | — | — | WO | disclosed |