Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389221 | 0.87 | GPR119 (0.51) | POLBALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5134790 | 0.86 | RHOA (0.46) | RHOAPOLBTDP1L3MBTL1CYP2C9 | |
| SCHEMBL5133026 | 0.83 | RHOA (0.45) | RHOAPOLBTDP1L3MBTL1CYP2C9 | |
| SCHEMBL4703083 | 0.82 | GPR119 (0.39) | POLBTDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL1070995 | 0.81 | GPR119 (0.43) | RHOAPOLBTDP1L3MBTL1CYP2C9 | |
| SCHEMBL2689490 | 0.80 | TDP1 (0.52) | RHOAPOLBTDP1L3MBTL1CYP2C9 | |
| SCHEMBL389244 | 0.80 | GPR119 (0.49) | POLBL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL389049 | 0.78 | MAPT (0.42) | POLBTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL14017958 | 0.76 | MAPT (0.48) | TDP1CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL4705011 | 0.75 | GPR119 (0.38) | POLBALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606282-A2 | PHENYL- AND PYRIDYLPIPEREIDINYE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | Arena Pharmaceuticals, Inc. (US) | 2005-12-21 | — | — | EP | claimed |
| WO-2004076413-A2 | PHENYL- AND PYRIDYLPIPERIDINE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | ARENA PHARMACEUTICALS, INC. (US) | 2004-09-10 | — | — | WO | claimed |