SCHEMBL6230188

SCHEMBL6230188

C=CC(=O)OCC(CO)CO

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.59
ALDH1A1 P00352 4/20 0.47
TP53 P04637 3/20 0.47
HIF1A Q16665 3/20 0.47
CYP3A4 P08684 2/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HSD17B10 Q99714 1/20 0.46
HPGD P15428 1/20 0.42
THRB P10828 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14463069 0.95 TSHR (0.59) TSHRALDH1A1TP53HIF1ACYP3A4
Acrylic Acid Methyl Ester SCHEMBL27697656 0.90 TSHR (0.55) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL12701633 0.88 TSHR (0.67) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL869655 0.88 TSHR (0.67) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL21638806 0.85 TSHR (0.50) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL8046526 0.83 HCAR2 (0.39) TSHRALDH1A1SMN1; SMN2THRB
SCHEMBL28265201 0.83 TSHR (0.66) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL21409688 0.83 TSHR (0.61) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL5027331 0.82 TSHR (0.79) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL25228296 0.80 TSHR (0.58) TSHRALDH1A1TP53HIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4921930-A ABRASION RESISTANT POLYESTERS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-05-01 US claimed
US-4910281-A Polyurethane from diol and diisocyanate MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-03-20 US claimed
EP-0309249-A2 Acryloyloxy and methacryloyloxy group-containing condensation polymers MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-03-29 EP claimed
US-4170671-A CORROSION RESISTANCE, ACRYLIC POLYMER AND CHROMIUM COMPOUND NIPPON PAINT CO., LTD. (JP) 1979-10-09 US claimed
CN-105906613-B Acrylate diol cyclic styrylpyridinium salt, and synthesis and application thereof 湖北固润科技股份有限公司 2020-07-21 CN disclosed
US-9513407-B2 Photochromic composition and optical article using photochromic composition TOKUYAMA CORPORATION (JP) 2016-12-06 US disclosed
US-9513407-B2 Photochromic composition and optical article using photochromic composition TOKUYAMA CORPORATION (JP) 2016-12-06 US disclosed
US-20140043586-A1 Photochromic Composition and Optical Article Using Photochromic Composition TOKUYAMA CORPORATION (JP) 2014-02-13 US disclosed
US-20140043586-A1 Photochromic Composition and Optical Article Using Photochromic Composition TOKUYAMA CORPORATION (JP) 2014-02-13 US disclosed
US-20050221108-A1 Surface-treated zinc based metal plated steel plate and method for production thereof JFE STEEL CORPORATION, A CORPORATION OF JAPAN (JP) 2005-10-06 US disclosed
EP-1518943-A1 SURFACE-TREATED ZINC BASED METAL PLATED STEEL PLATE AND METHOD FOR PRODUCTION THEREOF JFE Steel Corporation (JP) 2005-03-30 EP disclosed
EP-1501831-A1 INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) WARNER-LAMBERT COMPANY LLC (US) 2005-02-02 EP disclosed
US-4921930-A ABRASION RESISTANT POLYESTERS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-05-01 US disclosed
US-4910281-A Polyurethane from diol and diisocyanate MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-03-20 US disclosed
US-4882215-A WEAR AND CORROSION RESISTANCE NIPPON PAINT CO., LTD. (JP) 1989-11-21 US disclosed
US-4880887-A METHACRYLATE CURABLE RESINS G-C TOSHI KOGYO CORPORATION (JP) 1989-11-14 US disclosed
EP-0309249-A2 Acryloyloxy and methacryloyloxy group-containing condensation polymers MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-03-29 EP disclosed
EP-0285460-A2 Precoated metal plate for heavy forming use Nippon Paint Co., Ltd. (JP) 1988-10-05 EP disclosed
US-4170671-A CORROSION RESISTANCE, ACRYLIC POLYMER AND CHROMIUM COMPOUND NIPPON PAINT CO., LTD. (JP) 1979-10-09 US disclosed
US-3953408-A LITHOGRAPHIC PLATES ASAHI KASEI KOGYO KABUSHIKI KAISHA (JA) 1976-04-27 US disclosed