SCHEMBL8046526

SCHEMBL8046526

O=C(/C=C/C(=O)OCC(CO)CO)OCC(CO)CO

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 7/20 0.39
ATM Q13315 1/20 0.39
TSHR P16473 2/20 0.38
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MAPT P10636 2/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
THRB P10828 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CACNA1B Q00975 1/20 0.32
APBA1 Q02410 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11437882 0.86 TSHR (0.49) HCAR2ATMTSHRKEAP1NFE2L2
SCHEMBL11437885 0.86 TSHR (0.49) HCAR2ATMTSHRKEAP1NFE2L2
SCHEMBL6230188 0.83 TSHR (0.59) TSHRALDH1A1THRBSMN1; SMN2
SCHEMBL6665040 0.80 LMNA (0.44) HCAR2ATMTSHRMAPTALDH1A1
SCHEMBL8940101 0.80 LMNA (0.44) HCAR2ATMTSHRMAPTALDH1A1
SCHEMBL4439685 0.80 LMNA (0.44) HCAR2ATMTSHRMAPTALDH1A1
SCHEMBL14463069 0.78 TSHR (0.59) TSHRALDH1A1THRBSMN1; SMN2
SCHEMBL1453623 0.77 TSHR (0.53) HCAR2ATMTSHRKEAP1NFE2L2
SCHEMBL11745052 0.77 TSHR (0.53) HCAR2ATMTSHRKEAP1NFE2L2
SCHEMBL6668015 0.77 HCAR2 (0.34) HCAR2ATMTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786495-B1 Thermoplastic polyester resin stretched film OJI YUKA SYNT PAPER CO LTD (JP) 2000-04-12 EP disclosed
US-5677055-A POLYESTER RESIN, MODIFIED OLEFIN OBTAINED BY GRAFT POLYMERIZING ALPHA, BETA-UNSATURATED CARBOXYLATE MONOMER CONTAINING HYDROXYL GROUPS AND AROMATIC VINYL MONOMER ONTO OLEFIN, POLYETHYLENE, EPOXY RESIN; RECORDING PAPER SUPPORT OJI-YUKA SYNTHETIC PAPER CO., LTD. (JP) 1997-10-14 US disclosed
EP-0786495-A2 Thermoplastic polyester resin stretched film OJI-YUKA SYNTHETIC PAPER CO., LTD. (JP) 1997-07-30 EP disclosed
EP-0612773-B1 Thermoplastic resin composition and process for preparing modified polyolefin type resin MITSUBISHI CHEM CORP (JP) 1996-12-27 EP disclosed
US-5424359-A Aromatic vinyl polymer having alpha, beta-unsaturated carboxylate having a hydroxyl group grafted onto it, and saturated polyester MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1995-06-13 US disclosed
EP-0612773-A1 Thermoplastic resin composition and process for preparing modified polyolefin type resin MITSUBISHI CHEMICAL CORPORATION (JP) 1994-08-31 EP disclosed