Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | VDR | P11473 | 10/20 | 0.44 |
| ▸ | AR | P10275 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230194 | 0.94 | HDAC6 (0.45) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL5504682 | 0.92 | GRIN2D (0.42) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL6227729 | 0.90 | HDAC6 (0.43) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL6225819 | 0.90 | HDAC6 (0.46) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL6228546 | 0.90 | HDAC6 (0.43) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL5504678 | 0.90 | VDR (0.41) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL6263044 | 0.85 | VDR (0.49) | VDRAR | |
| SCHEMBL6262001 | 0.85 | HDAC6 (0.44) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL6226502 | 0.85 | HDAC6 (0.44) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL6225816 | 0.84 | HDAC6 (0.46) | HDAC6HDAC3HDAC1VDRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587906-A2 | VESICANT TREATMENT WITH PHENYL-PHENYL TYPE VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1565422-A1 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004063345-A2 | VESICANT TREATMENT WITH PHENYL-PHENYL TYPE VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |
| WO-2004048309-A1 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |