Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | VDR | P11473 | 8/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504678 | 0.96 | VDR (0.41) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL5506631 | 0.92 | GRIN2D (0.40) | GRIN2DGRIN2AGRIN2BGRIN2CVDR | |
| SCHEMBL6230198 | 0.92 | HDAC6 (0.45) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL6230194 | 0.90 | HDAC6 (0.45) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL6228546 | 0.88 | HDAC6 (0.43) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL6227729 | 0.88 | HDAC6 (0.43) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL5507815 | 0.86 | VDR (0.45) | GRIN2DGRIN2AGRIN2BGRIN2CVDR | |
| SCHEMBL5971424 | 0.85 | LMNA (0.41) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL5971989 | 0.84 | HDAC6 (0.40) | VDRHDAC6HDAC3HDAC1AR | |
| SCHEMBL5971475 | 0.84 | HDAC6 (0.39) | VDRHDAC6HDAC3HDAC1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836151-A2 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069153-A2 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-06-29 | — | — | WO | disclosed |