Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231015 | 1.00 | CA12 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20153503 | 0.81 | CA12 (0.60) | CA12CA1CA2CA7CA9 | |
| SCHEMBL22092369 | 0.79 | CA12 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL22092367 | 0.79 | CA12 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1914006 | 0.78 | CA12 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1914010 | 0.78 | CA12 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20153690 | 0.78 | CA12 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20153730 | 0.78 | CA12 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20153775 | 0.78 | TTR (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7469291 | 0.78 | P4HTM (0.49) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121160-A2 | 11, 12 CYCLIC THIOCARBAMATE MACROLIDE ANTIBACTERIAL AGENTS | JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050250713-A1 | 11,12-Cyclic thiocarbamate macrolide antibacterial agents | ZHU BIN | 2005-11-10 | — | — | US | disclosed |
| EP-1513856-A1 | 3-DESCLADINOSYL-6-O-CARBAMOYL AND 6-O-CARBONOYL MACROLIDE ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-03-16 | — | — | EP | disclosed |
| US-6825172-B2 | BACTERICIDES; AGAINST GRAMNEGATIVE, GRAMPOSITIVE BACTERIA | JANSSEN PHARMACEUTICA, NV (BE) | 2004-11-30 | — | — | US | disclosed |
| US-20040018994-A1 | 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-01-29 | — | — | US | disclosed |
| WO-2003102010-A1 | 3-DESCLADINOSYL-6-O-CARBAMOYL AND 6-O-CARBONOYL MACROLIDE ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250713-A1 | 11,12-Cyclic thiocarbamate macrolide antibacterial agents | MRPL21, TTC14, MRPL12 | CA12 2911/4885CA1 4803/4885CA2 3723/4885 |
| US-20040018994-A1 | 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents | CHCHD6, MRPL21, MRPS18B | CA12 4084/4885CA1 4647/4885CA2 3204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.