Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920469 | 0.89 | ALDH1A1 (0.47) | TACR1CYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL8337162 | 0.83 | ALDH1A1 (0.49) | TACR1CYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4705370 | 0.79 | ALDH1A1 (0.48) | CYP2C9CYP3A4CYP2C19ALDH1A1MEN1 | |
| SCHEMBL13920467 | 0.77 | FAAH (0.44) | NAMPT | |
| SCHEMBL20491159 | 0.76 | TACR1 (0.51) | TACR1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10179506 | 0.76 | ALDH1A1 (0.46) | CYP2C9CYP3A4CYP2C19ALDH1A1MEN1 | |
| SCHEMBL13374225 | 0.76 | ALDH1A1 (0.46) | CYP2C9CYP3A4CYP2C19ALDH1A1MEN1 | |
| SCHEMBL11958663 | 0.76 | ALDH1A1 (0.48) | CYP2C9CYP3A4CYP2C19ALDH1A1MEN1 | |
| SCHEMBL4706451 | 0.75 | ALDH1A1 (0.43) | TACR1CYP2C9CYP3A4CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4210812 | 0.75 | ALDH1A1 (0.47) | CYP2C9CYP3A4CYP2C19ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-A1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052851-A1 | PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |