Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236871 | 0.89 | SMN1; SMN2 (0.66) | TP53SMN1; SMN2PTPN11POLBMAPT | |
| SCHEMBL6233225 | 0.88 | POLB (0.51) | TP53SMN1; SMN2POLBMAPTMAPK8 | |
| SCHEMBL6236745 | 0.86 | SLC2A1 (0.54) | THRBTP53SMN1; SMN2MAPTGAA | |
| SCHEMBL6235130 | 0.85 | MAPT (0.48) | TP53SMN1; SMN2TDP2MAPTEGFR | |
| SCHEMBL6231629 | 0.84 | TP53 (0.43) | THRBTP53SMN1; SMN2MAPTEGFR | |
| SCHEMBL6231898 | 0.84 | TP53 (0.43) | THRBTP53SMN1; SMN2POLBMAPT | |
| SCHEMBL6235684 | 0.84 | TP53 (0.43) | TP53SMN1; SMN2MAPTGAAEGFR | |
| SCHEMBL6232210 | 0.82 | MAPT (0.45) | THRBTP53SMN1; SMN2POLBMAPT | |
| SCHEMBL6235106 | 0.78 | SMN1; SMN2 (0.69) | TP53SMN1; SMN2PTPN11POLBMAPT | |
| SCHEMBL6234312 | 0.78 | SMN1; SMN2 (0.65) | THRBTP53SMN1; SMN2PTPN11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |