Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6229818 | 0.89 | CCNC (0.48) | TP53SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL6234079 | 0.88 | SLC2A1 (0.50) | TP53SMN1; SMN2MAPTMEN1HTT | |
| SCHEMBL6235130 | 0.88 | MAPT (0.48) | TP53SMN1; SMN2MAPTMEN1LMNA | |
| SCHEMBL6236745 | 0.87 | SLC2A1 (0.54) | TP53SMN1; SMN2MAPTMEN1LMNA | |
| SCHEMBL6231898 | 0.87 | TP53 (0.43) | TP53SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL6235684 | 0.87 | TP53 (0.43) | TP53SMN1; SMN2MAPTMEN1LMNA | |
| SCHEMBL6233830 | 0.84 | SMN1; SMN2 (0.65) | TP53SMN1; SMN2MAPTMEN1LMNA | |
| SCHEMBL6231880 | 0.84 | THRB (0.55) | TP53SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL6235371 | 0.80 | MAPT (0.42) | TP53SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL6235697 | 0.80 | NPY5R (0.39) | TP53SMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |