Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233063 | 0.88 | SLC2A1 (0.71) | SLC2A1TP53SMN1; SMN2MAPK13MAPK12 | |
| SCHEMBL6235130 | 0.88 | MAPT (0.48) | SLC2A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL6231629 | 0.87 | TP53 (0.43) | SLC2A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL6231898 | 0.87 | TP53 (0.43) | SLC2A1TP53SMN1; SMN2MAPTGAA | |
| SCHEMBL6235684 | 0.87 | TP53 (0.43) | TP53SMN1; SMN2MAPK13MAPK12MAPK11 | |
| SCHEMBL6231880 | 0.86 | THRB (0.55) | TP53SMN1; SMN2MAPK14MAPTGAA | |
| SCHEMBL6235106 | 0.85 | SMN1; SMN2 (0.69) | SLC2A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL6231640 | 0.80 | SLC2A1 (0.48) | SLC2A1TP53SMN1; SMN2MAPK13MAPK12 | |
| SCHEMBL6087219 | 0.79 | TP53 (0.52) | SLC2A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL6087819 | 0.77 | TP53 (0.50) | SLC2A1TP53SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |