Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231904 | 0.95 | CA1 (0.41) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6231125 | 0.94 | PIM1 (0.47) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6232252 | 0.93 | LMNA (0.42) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6239738 | 0.93 | CA1 (0.50) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6233755 | 0.91 | PIM1 (0.40) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6233199 | 0.90 | CYP19A1 (0.42) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6233754 | 0.83 | MAPK13 (0.40) | CA1CA2CA9LMNAMEN1 | |
| SCHEMBL6232338 | 0.81 | CA1 (0.44) | PIM1CLK4AXLPTK2BMAPKAPK5 | |
| SCHEMBL6231824 | 0.79 | TUBB4A (0.42) | PIM1CLK4CA1CA2CA9 | |
| SCHEMBL6236235 | 0.79 | KDM4E (0.39) | PIM1CLK4AXLPTK2BMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004582-B1 | Pyridazino quinoline compounds | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |
| EP-0790996-B1 | PYRIDAZINOQUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-03-27 | — | — | EP | disclosed |
| US-6232313-B1 | TREATING STROKE OR EPILEPTIC CONVULSIONS ASSOCIATED WITH EXCESSIVE CALCIUM INFLUX IN THE BRAIN CAUSED BY EXCITATORY AMINO ACIDS | ZENECA LIMITED (GB) | 2001-05-15 | — | — | US | disclosed |
| US-6214826-B1 | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 2001-04-10 | — | — | US | disclosed |
| EP-0724583-B1 | PYRIDAZINO QUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| EP-1004582-A2 | Pyridazino quinoline compounds | AstraZeneca UK Limited (GB) | 2000-05-31 | — | — | EP | disclosed |
| US-5744471-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1998-04-28 | — | — | US | disclosed |
| EP-0790996-A1 | PYRIDAZINOQUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| EP-0724583-A1 | PYRIDAZINO QUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1996015127-A1 | PYRIDAZINOQUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |
| WO-1995011244-A1 | PYRIDAZINO QUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1995-04-27 | — | — | WO | disclosed |