Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822021 | 0.78 | KMT2A (0.35) | SMN1; SMN2LMNAALDH1A1KDM4EDRD2 | |
| SCHEMBL28710222 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18085976 | 0.76 | NPC1 (0.37) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL5609138 | 0.72 | PDE4B (0.36) | LMNAKDM4ENPC1RAB9A | |
| SCHEMBL18739643 | 0.71 | HSD17B10 (0.55) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9021346 | 0.71 | ALDH1A1 (0.38) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18555663 | 0.70 | KDM4E (0.41) | SMN1; SMN2LMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL24719504 | 0.70 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL29931828 | 0.70 | NPC1 (0.58) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL341046 | 0.70 | NPC1 (0.58) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213287-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-25 | — | — | EP | disclosed |
| US-6730687-B1 | THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| EP-1213287-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |