SCHEMBL6232146

SCHEMBL6232146

[c]1ccc(CCN2CCNCC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 3/20 0.55
KCNJ1 P48048 2/20 0.55
SIGMAR1 Q99720 5/20 0.54
SLC6A4 P31645 2/20 0.53
SLC6A3 Q01959 2/20 0.50
SLC6A2 P23975 1/20 0.50
POLB P06746 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HRH3 Q9Y5N1 3/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
MBTD1 Q05BQ5 1/20 0.43
L3MBTL3 Q96JM7 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
CXCR4 P61073 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28158380 0.88 SIGMAR1 (0.63) KCNH2KCNJ1SIGMAR1SLC6A4POLB
SCHEMBL8722548 0.86 KCNH2 (0.50) KCNH2KCNJ1SIGMAR1SLC6A4SLC6A3
SCHEMBL2587783 0.82 SLC6A3 (0.64) SIGMAR1SLC6A3HRH3L3MBTL1MBTD1
SCHEMBL9367020 0.81 HRH3 (0.66) SIGMAR1SLC6A3HRH3L3MBTL1MBTD1
SCHEMBL3963041 0.81 SIGMAR1 (0.79) KCNH2KCNJ1SIGMAR1SLC6A4SLC6A3
SCHEMBL759019 0.81 SIGMAR1 (0.66) SIGMAR1HRH3TDP1CXCR4
SCHEMBL41969 0.81 SIGMAR1 (0.79) KCNH2KCNJ1SIGMAR1SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL2195558 0.79 SIGMAR1 (0.77) KCNH2KCNJ1SIGMAR1SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL16739273 0.79 SIGMAR1 (0.77) KCNH2KCNJ1SIGMAR1SLC6A4SLC6A3
SCHEMBL29393817 0.79 SIGMAR1 (0.77) KCNH2KCNJ1SIGMAR1SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0836613-B1 WATER-SOLUBLE ADENOSINE KINASE INHIBITORS METABASIS THERAPEUTICS INC (US) 2005-05-25 EP claimed
US-5795977-A Water soluble adenosine kinase inhibitors METABASIS THERAPEUTICS, INC. (US) 1998-08-18 US claimed
EP-0836613-A1 WATER-SOLUBLE ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1998-04-22 EP claimed
WO-1996040707-A1 WATER-SOLUBLE ADENOSINE KINASE INHIBITORS GENSIA SICOR (US) 1996-12-19 WO claimed
EP-0832091-B1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA SICOR INC (US) 2004-01-14 EP disclosed
CN-1190401-A C-4' modified adenosine kinase inhibitors GENSIA INC (US) 1998-08-12 CN disclosed