Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 13/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.59 |
| ▸ | CTSV | O60911 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828397 | 0.89 | WEE1 (0.70) | WEE1CHEK1CTSVCTSLPDGFRB | |
| SCHEMBL5828032 | 0.86 | WEE1 (0.70) | WEE1CHEK1CTSVCTSLPDGFRB | |
| SCHEMBL5829115 | 0.85 | WEE1 (0.71) | WEE1CHEK1GSK3BCDK5CDK2 | |
| SCHEMBL5827617 | 0.83 | WEE1 (0.74) | WEE1CHEK1CTSVCTSLPDGFRB | |
| SCHEMBL5827976 | 0.83 | WEE1 (0.77) | WEE1CHEK1PDGFRBROCK2GSK3B | |
| SCHEMBL5829332 | 0.81 | WEE1 (0.73) | WEE1CHEK1PDGFRBROCK2 | |
| SCHEMBL5829421 | 0.79 | WEE1 (0.70) | WEE1CHEK1PDGFRBROCK2CCNE1 | |
| SCHEMBL5828572 | 0.79 | WEE1 (0.72) | WEE1CHEK1 | |
| SCHEMBL5828726 | 0.78 | WEE1 (0.83) | WEE1CHEK1PDGFRBROCK2GSK3B | |
| SCHEMBL5829311 | 0.78 | CTSV (0.58) | WEE1CHEK1CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |