Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624101 | 0.90 | MAPT (0.46) | MAPTKDM4EGAANPSR1PKM | |
| SCHEMBL623301 | 0.83 | MAPT (0.49) | MAPTKDM4EGAANPSR1PKM | |
| SCHEMBL14261377 | 0.73 | ALDH1A1 (0.54) | MAPTKDM4EGAANPSR1ALDH1A1 | |
| SCHEMBL623383 | 0.72 | MAPT (0.52) | MAPTKDM4EGAANPSR1PKM | |
| SCHEMBL937821 | 0.69 | ADORA1 (0.65) | MAPTKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL16007549 | 0.68 | ADORA1 (0.72) | MAPTKDM4EGAANPSR1PKM | |
| SCHEMBL624102 | 0.67 | ADORA1 (0.49) | MAPTKDM4EGAAATMALDH1A1 | |
| SCHEMBL16020430 | 0.65 | NPSR1 (0.55) | MAPTKDM4EGAANPSR1PKM | |
| SCHEMBL16017714 | 0.64 | ADORA1 (0.57) | MAPTKDM4EGAANPSR1PKM | |
| SCHEMBL624426 | 0.63 | MAPT (0.41) | MAPTKDM4EGAAATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020227-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |