Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623301 | 0.89 | MAPT (0.49) | MAPTKDM4EGAAADORA1TP53 | |
| SCHEMBL22392258 | 0.85 | MEN1 (0.56) | MAPTGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9425818 | 0.85 | ALDH1A1 (0.47) | MAPTKDM4EGAATP53NPSR1 | |
| SCHEMBL622747 | 0.84 | ADORA1 (0.52) | MAPTKDM4EGAAADORA1ALDH1A1 | |
| SCHEMBL624101 | 0.84 | MAPT (0.46) | MAPTKDM4EGAAADORA1TP53 | |
| SCHEMBL22392265 | 0.79 | ALDH1A1 (0.46) | MAPTKDM4EGAAADORA1ALDH1A1 | |
| SCHEMBL11559664 | 0.79 | MAPT (0.46) | MAPTKDM4EGAAADORA1TP53 | |
| SCHEMBL9437227 | 0.78 | DRD4 (0.46) | MAPTKDM4EGAAALDH1A1HPGD | |
| SCHEMBL16007549 | 0.76 | ADORA1 (0.72) | MAPTKDM4EGAAADORA1TP53 | |
| SCHEMBL8093726 | 0.75 | KDM4E (0.41) | MAPTKDM4EGAAADORA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020227-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |