SCHEMBL6232589

SCHEMBL6232589

COCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccc(S(=O)(=O)[O-])cc1

nearest known ligand 0.40

Known targets — ChEMBL curated mechanism

CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
HTT P42858 3/20 0.40
LMNA P02545 3/20 0.40
HPGD P15428 1/20 0.40
HIF1A Q16665 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CYP3A4 P08684 2/20 0.39
MAPK1 P28482 2/20 0.39
CYP2D6 P10635 2/20 0.39
TRAP1 Q12931 1/20 0.39
THPO P40225 1/20 0.39
CA12 O43570 3/20 0.37
CA9 Q16790 3/20 0.37
CYP1A2 P05177 2/20 0.37
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
ATM Q13315 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
KDM4E B2RXH2 2/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9634534 0.88 HIF1A (0.52) ALDH1A1HTTLMNAHPGDHIF1A
SCHEMBL6232586 0.82 HIF1A (0.38) ALDH1A1HTTHIF1AMAPK1CYP2D6
SCHEMBL9634538 0.81 ALDH1A1 (0.51) ALDH1A1LMNAHIF1ACYP3A4MAPK1
Butyltriphenylphosphonium SCHEMBL6928248 0.81 CNR2 (0.45) ALDH1A1HTTLMNAHIF1ASMN1; SMN2
SCHEMBL6230992 0.80 CYP3A4 (0.46) ALDH1A1HTTLMNAHPGDSMN1; SMN2
SCHEMBL10484490 0.80 HIF1A (0.43) ALDH1A1LMNAHIF1ACYP3A4MAPK1
SCHEMBL10484434 0.79 TDP1 (0.49) ALDH1A1LMNACYP3A4CYP1A2POLB
SCHEMBL9634519 0.79 NR1I2 (0.48) ALDH1A1HTTLMNAHIF1ASMN1; SMN2
SCHEMBL9675753 0.79 NR1I2 (0.48) ALDH1A1HTTLMNAHIF1ASMN1; SMN2
Phenylmethanesulfonic Acid SCHEMBL6232593 0.78 HIF1A (0.40) ALDH1A1HTTHPGDHIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6037114-A A THERMOSENSITIVE ELEMENT COMPRISING AN ORGANIC SILVER SALT AND A REDUCING AGENT EXHIBITING A NEUTRAL IMAGE TONE EXHIBIT AN INCREASE IN MAXIMUM IMAGE DENSITY AND IMAGE GRADATION UPON INCORPORATING A NON-HALIDE POLYARYLONIUM COMPOUND AGFA-GEVAERT (BE) 2000-03-14 US claimed
EP-0848286-B1 Thermographic recording material with improved image tone and/or stability upon thermal development AGFA GEVAERT (BE) 2005-04-06 EP disclosed
EP-0921434-B1 Thermographic recording material with improved image density and/or image gradation upon thermal development AGFA GEVAERT (BE) 2003-07-09 EP disclosed
US-6579671-B2 Comprises silver behenate, silver palmitate, and silver stearate; for thermographic or photothermographic development; x-rays AGFA-GEVAERT (BE) 2003-06-17 US disclosed
US-20020150849-A1 Recording materials with improved shelf-life, image tone and /or stability upon thermal development AGFA-GEVAERT (BE) 2002-10-17 US disclosed
US-6159667-A Thermographic recording material with improved image tone and/or stability upon thermal development AGFA-GEVAERT (BE) 2000-12-12 US disclosed
US-6096486-A SUPPORT, THERMOSENSITIVE ELEMENT CONTAINING SILVER BEHENATE, ORGANIC REDUCING AGENT, AND A BINDER, WHERE THE SILVER BEHENATE IS NOT ASSOCIATED WITH MERCURY OR LEAD IONS, HAS SPECIFIED X-RAY CHARACTERISTICS, AND INCREASED CRYSTALLINITY AGFA-GEVAERT (BE) 2000-08-01 US disclosed
US-6037114-A A THERMOSENSITIVE ELEMENT COMPRISING AN ORGANIC SILVER SALT AND A REDUCING AGENT EXHIBITING A NEUTRAL IMAGE TONE EXHIBIT AN INCREASE IN MAXIMUM IMAGE DENSITY AND IMAGE GRADATION UPON INCORPORATING A NON-HALIDE POLYARYLONIUM COMPOUND AGFA-GEVAERT (BE) 2000-03-14 US disclosed
EP-0921434-A1 Thermographic recording material with improved image density and/or image gradation upon thermal development AGFA-GEVAERT N.V. (BE) 1999-06-09 EP disclosed
EP-0848286-A1 Thermographic recording material with improved image tone and/or stability upon thermal development AGFA-GEVAERT N.V. (BE) 1998-06-17 EP disclosed