Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043124 | 0.90 | POLB (0.34) | TAS1R3TAS1R1NPC1RAB9ATSHR | |
| SCHEMBL4043857 | 0.88 | CTSK (0.44) | CTSK | |
| SCHEMBL4041145 | 0.87 | CTSK (0.45) | NPC1RAB9ATSHRCTSKMAPK1 | |
| SCHEMBL4040234 | 0.87 | CTSK (0.54) | NPC1RAB9ACTSKALDH1A1LMNA | |
| SCHEMBL4039055 | 0.86 | CTSK (0.54) | RAB9ACTSKALDH1A1 | |
| SCHEMBL4041463 | 0.86 | CTSK (0.43) | TAS1R3TAS1R1RAB9ACTSKKMT2A | |
| SCHEMBL4041112 | 0.86 | CTSK (0.46) | CTSK | |
| SCHEMBL4040030 | 0.86 | CTSK (0.41) | NPC1RAB9ACTSKSMN1; SMN2 | |
| SCHEMBL4040328 | 0.85 | CTSK (0.42) | TAS1R3TAS1R1CTSK | |
| SCHEMBL4045200 | 0.85 | CTSK (0.45) | NPC1RAB9ACTSKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |