Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039972 | 0.93 | CTSK (0.40) | POLBTSHRLMNAHPGDSMN1; SMN2 | |
| SCHEMBL4050093 | 0.90 | HTT (0.41) | TSHRLMNAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6232613 | 0.90 | TAS1R3 (0.44) | TSHRLMNAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL4051965 | 0.90 | MC4R (0.38) | LMNASMN1; SMN2ALDH1A1KDM4ECTSK | |
| SCHEMBL4043650 | 0.89 | BMP1 (0.36) | POLBTSHRLMNAHPGDSMN1; SMN2 | |
| SCHEMBL4043596 | 0.88 | ELANE (0.38) | TSHRALDH1A1CTSKELANE | |
| SCHEMBL4046061 | 0.88 | LMNA (0.36) | POLBTSHRLMNAHPGDSMN1; SMN2 | |
| SCHEMBL4044339 | 0.87 | ALDH1A1 (0.37) | LMNAALDH1A1RAB9ACTSKELANE | |
| SCHEMBL4051473 | 0.87 | CTSK (0.34) | ALDH1A1CTSKELANE | |
| SCHEMBL4045553 | 0.86 | CTSK (0.34) | ALDH1A1CTSKELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |