SCHEMBL6232619

SCHEMBL6232619

CC(C)(C)OC(=O)C(Oc1cncc(Br)c1)[C@@H]1CCN1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CHRNB2 P17787 2/20 0.34
CHRNA4 P43681 2/20 0.34
UCHL1 P09936 1/20 0.34
USP30 Q70CQ3 1/20 0.34
EPAS1 Q99814 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C19 P33261 1/20 0.33
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8585735 1.00 NPC1 (0.37) NPC1RAB9ASMN1; SMN2CHRNB2CHRNA4
SCHEMBL5806257 0.95 NPC1 (0.35) NPC1RAB9ASMN1; SMN2CHRNB2CHRNA4
SCHEMBL7412173 0.88 CHRNB4 (0.40) CHRNB2CHRNA4
SCHEMBL7415277 0.87 CHRNB2 (0.32) CHRNB2CHRNA4
SCHEMBL7410563 0.86 CHRNB2 (0.38) CHRNB2CHRNA4
SCHEMBL8508512 0.84 CHRNB2 (0.35) CHRNB2CHRNA4
SCHEMBL7459126 0.84 NPC1 (0.35) NPC1RAB9ASMN1; SMN2CHRNB2CHRNA4
SCHEMBL8507157 0.83 CHRNB2 (0.47) CHRNB2CHRNA4USP30
SCHEMBL7412863 0.82
SCHEMBL7411624 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005000806-A2 LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, AND METHODS OF MAKING AND USING THEM GEORGETOWN UNIVERSITY (US) 2005-01-06 WO disclosed
EP-0950057-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS Abbott Laboratories (US) 1999-10-20 EP disclosed
EP-0934308-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1999-08-11 EP disclosed
WO-1998025920-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LABORATORIES (US) 1998-06-18 WO disclosed
WO-1997046554-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-12-11 WO disclosed