Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415277 | 0.89 | CHRNB2 (0.32) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6232619 | 0.88 | NPC1 (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL7410563 | 0.88 | CHRNB2 (0.38) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8585735 | 0.88 | NPC1 (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL8508512 | 0.85 | CHRNB2 (0.35) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8507157 | 0.85 | CHRNB2 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7411997 | 0.83 | YAP1 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7413499 | 0.83 | CHRNB4 (0.34) | CHRNB4CHRNA3 | |
| SCHEMBL5806257 | 0.83 | NPC1 (0.35) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8508466 | 0.83 | CHRNB2 (0.33) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| EP-0950057-A1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | Abbott Laboratories (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |
| WO-1998025920-A1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LABORATORIES (US) | 1998-06-18 | — | — | WO | disclosed |