Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079221 | 0.85 | MAOB (0.45) | HTR1ASMN1; SMN2RXRAGRIN1GRIN2B | |
| SCHEMBL6079731 | 0.80 | RXRA (0.40) | SLC6A4SLC6A2SLC6A3SGMS2RXRA | |
| SCHEMBL6078807 | 0.76 | RAB9A (0.51) | SGMS2 | |
| SCHEMBL6242298 | 0.73 | RAB9A (0.46) | SGMS2 | |
| SCHEMBL18339340 | 0.70 | KCNH2 (0.38) | SGMS2KCNH2 | |
| SCHEMBL2892451 | 0.69 | SLC6A4 (0.50) | KMT2ASLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL27722152 | 0.69 | SLC6A4 (0.50) | KMT2AHTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL38662084 | 0.67 | HDAC8 (0.61) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL5860852 | 0.66 | TSHR (0.47) | KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL6080064 | 0.66 | MAOB (0.53) | KMT2AHTR1ASMN1; SMN2SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |