Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68891 | 0.90 | KDM4E (0.51) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL28703252 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9631891 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL70017 | 0.83 | ALDH1A1 (0.61) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL30034075 | 0.83 | ALDH1A1 (0.61) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9630469 | 0.82 | ALDH1A1 (0.55) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL28389068 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Water SCHEMBL10472756 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL9622111 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Water SCHEMBL10410161 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004582-B1 | Pyridazino quinoline compounds | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |
| US-6737424-B2 | THERAPY FOR NERVOUS SYSTEM DISORDERS | ZENECA LTD. (GB) | 2004-05-18 | — | — | US | disclosed |
| US-6214826-B1 | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 2001-04-10 | — | — | US | disclosed |
| EP-0724583-B1 | PYRIDAZINO QUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| CN-1053189-C | pyridazino quinoline compounds | ZENECA LTD (GB) | 2000-06-07 | — | — | CN | disclosed |
| EP-1004582-A2 | Pyridazino quinoline compounds | AstraZeneca UK Limited (GB) | 2000-05-31 | — | — | EP | disclosed |
| CN-1138332-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1996-12-18 | — | — | CN | disclosed |