SCHEMBL6232895

SCHEMBL6232895

O=C(CO)N1CCC(c2ccc(N3C[C@H](CNC(=S)C(F)F)OC3=O)cc2F)CC1

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.53
MAOB P27338 4/20 0.47
MAOA P21397 5/20 0.47
LMNA P02545 1/20 0.47
PTGS1 P23219 1/20 0.47
CALML3 P27482 1/20 0.47
SDHA P31040 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6249323 0.89 F10 (0.56) F10MAOBMAOALMNAPTGS1
SCHEMBL4883262 0.88 F10 (0.50) F10MAOBMAOALMNAPTGS1
SCHEMBL14197116 0.88 F10 (0.50) F10MAOBMAOALMNAPTGS1
SCHEMBL6402337 0.88 MAOA (0.61) F10MAOBMAOALMNAPTGS1
SCHEMBL6402339 0.88 MAOA (0.61) F10MAOBMAOALMNAPTGS1
SCHEMBL5739519 0.88 MAOA (0.48) F10MAOBMAOALMNAPTGS1
SCHEMBL6398185 0.87 F10 (0.55) F10MAOBMAOALMNAPTGS1
SCHEMBL6398188 0.87 F10 (0.55) F10MAOBMAOALMNAPTGS1
SCHEMBL6704404 0.87 F10 (0.49) F10MAOB
SCHEMBL2949084 0.86 F10 (0.69) F10MAOBMAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040072842-A1 Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent PHARMACIA & UPJOHN COMPANY 2004-04-15 US claimed
EP-1519722-A1 GLYCOLOYL-SUBSTITUTED OXAZOLIDINONE-DERIVATIVES AS ANTIBACTERIAL AGENTS Pharmacia & Upjohn Company LLC (US) 2005-04-06 EP disclosed
US-20040072842-A1 Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent PHARMACIA & UPJOHN COMPANY 2004-04-15 US disclosed
WO-2004002479-A1 GLYCOLOYL-SUBSTITUTED OXAZOLIDINONE-DERIVATIVES AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2004-01-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040072842-A1 Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent GMDS, PGLS, DDOST F10 4107/4885MAOB 3566/4885MAOA 3409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.