Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.62 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14117214 | 0.84 | PARP10 (0.62) | PARP10PARP15ALDH1A1PARP14MAPT | |
| SCHEMBL435043 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAOBMAPTNPSR1TUBB1 | |
| SCHEMBL6235089 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAOBMAPTNPSR1TUBB1 | |
| SCHEMBL19849662 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MAOBTUBB1MEN1KMT2A | |
| SCHEMBL19839152 | 0.79 | ALDH1A1 (0.51) | PARP10PARP15ALDH1A1MAOBMAPT | |
| SCHEMBL29724497 | 0.79 | ALDH1A1 (0.51) | PARP10PARP15ALDH1A1MAOBMAPT | |
| SCHEMBL31591495 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MAOBMAPTTUBB1L3MBTL1 | |
| SCHEMBL6688713 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MAOBMAPTTUBB1L3MBTL1 | |
| SCHEMBL31591491 | 0.78 | MAOB (0.60) | PARP10ALDH1A1MAOBMAPTTUBB1 | |
| SCHEMBL15475165 | 0.77 | ALDH1A1 (0.59) | PARP10ALDH1A1MAOBMAPTTUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005054206-A1 | HISTIDINE DERIVATIVES | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-06-16 | — | — | WO | disclosed |
| EP-1533302-A1 | Histidine derivatives | Newron Pharmaceuticals S.p.A. (IT) | 2005-05-25 | — | — | EP | disclosed |