SCHEMBL6233331

SCHEMBL6233331

Fc1ccccc1Oc1[c]cccc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 8/20 0.39
HTR1A P08908 7/20 0.39
SLC6A3 Q01959 4/20 0.39
CXCL8 P10145 2/20 0.39
ALDH1A1 P00352 1/20 0.39
ESR1 P03372 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
PARP10 Q53GL7 1/20 0.39
KDM4E B2RXH2 2/20 0.38
MAPT P10636 1/20 0.38
CRHBP P24387 1/20 0.38
CRHR2 Q13324 1/20 0.38
RHEB Q15382 1/20 0.38
SLC6A4 P31645 1/20 0.36
HSPB1 P04792 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1532056 0.87 HSPB1 (0.36) SLC6A2HTR1ASLC6A3ALDH1A1MEN1
SCHEMBL1221858 0.87 KDM4E (0.39) SLC6A2HTR1ASLC6A3KDM4EMAPT
SCHEMBL19743246 0.85 KDM4E (0.34) KDM4EMAPTCRHBPCRHR2
SCHEMBL1532131 0.85 HSPB1 (0.49) ALDH1A1HSPB1L3MBTL1
SCHEMBL10965997 0.85 KDM4E (0.35) ALDH1A1KDM4EMAPTCRHBPCRHR2
SCHEMBL1532111 0.82 SLC6A2 (0.35) SLC6A2HTR1ASLC6A3SLC6A4
SCHEMBL1532070 0.79 KDM4E (0.35) KDM4EMAPTCRHBPCRHR2
SCHEMBL152163 0.78 LTA4H (0.32)
SCHEMBL4832971 0.77 KDM4E (0.37) SLC6A2HTR1ASLC6A3KDM4EMAPT
SCHEMBL3952656 0.76 PARP10 (0.42) SLC6A2HTR1ASLC6A3CXCL8ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022012550-A1 SUBSTITUTED 1H-IMIDAZO [1, 2-B] PYRAZOLE-3-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS HENAN NORMAL UNIVERSITY (CN) 2022-01-20 WO claimed
EP-3475286-A1 SUBSTITUTED PYRROLO [2, 3-D]PYRIDAZIN-4-ONES AND PYRAZOLO [3, 4-D]PYRIDAZIN-4-ONES AS PROTEIN KINASE INHIBITORS Shanghai Fochon Pharmaceutical Co., Ltd. (CN) 2019-05-01 EP claimed
WO-2017219955-A1 SUBSTITUTED PYRROLO [2, 3-D] PYRIDAZIN-4-ONES AND PYRAZOLO [3, 4-D] PYRIDAZIN-4-ONES AS PROTEIN KINASE INHIBITORS SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) 2017-12-28 WO claimed
US-9505753-B2 Inhibitors of D-amino acid oxidase THE JOHNS HOPKINS UNIVERSITY (US) 2016-11-29 US claimed
US-RE37087-E1 1-(4-ETHOXYPHENYL)-4-(4-FLUORO-3-PHENOXYPHENYL)-1 -TRIFLUOROMETHYLBUTANE OR 1-(4-ETHOXY-3-FLUOROPHENYL)-4-(3-PHENOXYPHENYL)-1-TRIFLUOROMETHYLBUTANE, FOR EXAMPLE; COMBATS INSECTS AND MITES SCHERING AKTIENGESELLSCHAFT (DE) 2001-03-06 US claimed
EP-0790981-B1 ARYLOXYCYCLOALKENYL AND ARYLOXYIMINOCYCLOALKENYLHYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS PFIZER (US) 1999-09-08 EP claimed
US-5798383-A Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas PFIZER INC. (US) 1998-08-25 US claimed
EP-0790981-A1 ARYLOXYCYCLOALKENYL AND ARYLOXYIMINOCYCLOALKENYLHYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 1997-08-27 EP claimed
WO-1996015106-A1 ARYLOXYCYCLOALKENYL AND ARYLOXYIMINOCYCLOALKENYLHYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 1996-05-23 WO claimed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US claimed
EP-0233834-B1 INSECTICIDAL TRIFLUORMETHYL ALKANE DERIVATIVES SCHERING AKTIENGESELLSCHAFT (DE) 1992-04-22 EP claimed
US-4791123-A MITICIDES SCHERING AKT. (DE) 1988-12-13 US claimed
US-4743622-A FLUORO COMPOUNDS SCHERING AKTIENGESELLSCHAFT (DE) 1988-05-10 US claimed
EP-0233834-A1 Insecticidal trifluormethyl alkane derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1987-08-26 EP claimed
US-4678811-A INSECTICIDES, MITICIDES SCHERING AKTIENGESELLSCHAFT (DE) 1987-07-07 US claimed
EP-0191723-A1 Aromatic alkane derivatives, pesticides containing these compounds and processes for their production SCHERING AKTIENGESELLSCHAFT (DE) 1986-08-20 EP claimed
EP-0179018-A1 Substituted benzyl ethers, pesticides containing these compounds and processes for their production SCHERING AKTIENGESELLSCHAFT (DE) 1986-04-23 EP claimed
EP-0136451-A2 Arylmethyl-ether derivatives, pesticides containing these compounds and process for their preparation SCHERING AKTIENGESELLSCHAFT (DE) 1985-04-10 EP claimed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed
US-4413003-A FUNGICIDES ROHM AND HAAS COMPANY (US) 1983-11-01 US disclosed