Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420235 | 0.86 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6885590 | 0.84 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3181116 | 0.83 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2995451 | 0.81 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6231315 | 0.80 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4637671 | 0.80 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL27537534 | 0.78 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6228583 | 0.78 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7395213 | 0.78 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7360077 | 0.78 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |