Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.71 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1485802 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL2812473 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL5370086 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL1123494 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL23494884 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL14877028 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL23494872 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL3027039 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL3029590 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL7632707 | 1.00 | MEN1 (0.74) | MEN1KMT2AMAPK1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1240537-C | Method of making a multilayer foam article and articles made therefrom | DOW GLOBAL TECHNOLOGIES INC (US) | 2006-02-08 | — | — | CN | disclosed |
| EP-1395422-B1 | PROCESS FOR PRODUCING A MULTI-LAYERED FOAM ARTICLE AND ARTICLES PRODUCED THEREFROM | DOW GLOBAL TECHNOLOGIES INC (US) | 2005-04-27 | — | — | EP | disclosed |
| CN-1537050-A | Method of making a multilayer foam article and articles made therefrom | — | 2004-10-13 | — | — | CN | disclosed |
| US-6787078-B2 | ADDING LIQUID ELASTOMER, SELECTIVELY APPLYING RELEASE AGENT TO MOLD, ADDING LIQUID FOAM BEFORE ELASTOMER IS COMPLETELY CURED; ELASTOMERIC LAYER IS INTEGRALLY ATTACHED TO THE FOAM IN THE AREAS NOT CONTAINING THE RELEASE AGENT; SEATS | DOW GLOBAL TECHNOLOGIES INC. | 2004-09-07 | — | — | US | disclosed |
| EP-1395422-A1 | PROCESS FOR PRODUCING A MULTI-LAYERED FOAM ARTICLE AND ARTICLES PRODUCED THEREFROM | Dow Global Technologies Inc. (US) | 2004-03-10 | — | — | EP | disclosed |
| US-20030098598-A1 | Process for producing a multi-layered foam article and articles produced therefrom | DOW GLOBAL TECHNOLOGIES INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2002102585-A1 | PROCESS FOR PRODUCING A MULTI-LAYERED FOAM ARTICLE AND ARTICLES PRODUCED THEREFROM | DOW GLOBAL TECHNOLOGIES INC. (US) | 2002-12-27 | — | — | WO | disclosed |
| US-4220727-A | CARBOXYALKYL SILOXANES, ALIPHATIC GLYOXIMES, ARALKYL QUATERNARY AMMONIUM SALTS | UNION CARBIDE CORPORATION (US) | 1980-09-02 | — | — | US | disclosed |
| US-4111861-A | ELASTOMERS | UNION CARBIDE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |