Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748980 | 0.98 | KEAP1 (0.50) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL10709838 | 0.83 | KEAP1 (0.48) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL15412916 | 0.79 | KEAP1 (0.46) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL19414026 | 0.78 | KEAP1 (0.48) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL4610363 | 0.76 | KEAP1 (0.43) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL1403926 | 0.76 | KEAP1 (0.50) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| Cyclohexylamine SCHEMBL28823963 | 0.74 | CHRM2 (0.44) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL846064 | 0.74 | KEAP1 (0.48) | KEAP1NFE2L2CHRM2CHRM1CHRM3 | |
| SCHEMBL5717261 | 0.74 | KEAP1 (0.48) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL31025938 | 0.74 | KEAP1 (0.48) | KEAP1NFE2L2KIF11CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115215755-B | Hydroxyl-containing di-secondary amine, preparation method and application thereof | 万华化学集团股份有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-115215755-A | Hydroxyl-containing bis-secondary amine, and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-117658824-B | Production of H with low content of trans-trans isomer12MDA method | 万华化学集团股份有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-118026853-B | Continuous hydrogenation synthesis of H with low content of anti-reflection body12MDA method | 万华化学集团股份有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-119822967-A | HMDA production method | 万华化学集团股份有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-118026853-A | Continuous hydrogenation synthesis of H with low content of anti-reflection body12MDA method | 万华化学集团股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-117658824-A | Production of H with low content of trans-trans isomer 12 MDA method | 万华化学集团股份有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-115215755-B | Hydroxyl-containing di-secondary amine, preparation method and application thereof | 万华化学集团股份有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-114163334-B | Modified alicyclic amine curing agent and preparation method thereof | 万华化学集团股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-115215755-A | Hydroxyl-containing bis-secondary amine, and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-114163334-A | Modified alicyclic amine curing agent and preparation method thereof | 万华化学集团股份有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-110078627-B | High-yield synthesis of H6Method for MDA | 万华化学集团股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-109851508-B | Synthesis of H with low trans-isomer content and low tar content12Method for MDA | 万华化学集团股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-109851508-B | Synthesis of H with low trans-isomer content and low tar content12Method for MDA | 万华化学集团股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| WO-2012092750-A1 | METHOD FOR INTERMITTENT PREPARATION OF LOW CONTENT TRANS-TRANS ISOMER-CONTAINING 4,4'-DIAMINODICYCLOHEXYLMETHANE | 烟台万华聚氨酯股份有限公司 (CN) | 2012-07-12 | — | — | WO | disclosed |
| EP-1519912-A2 | PROCESS FOR INCREASING THE SELECTIVITY OF THE HYDROGENATION OF 4,4'-DIAMINODIPHENYLMETHANE TO 4,4'-DIAMINODICYCLOHEXYLMETHANE IN THE PRESENCE OF AN N-ALKYL-4,4'-DIAMINODIPHENYLMETHANE | Degussa AG (DE) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004007425-A2 | PROCESS FOR INCREASING THE SELECTIVITY OF THE HYDROGENATION OF 4,4'-DIAMINODIPHENYLMETHANE TO 4,4'-DIAMINODICYCLOHEXYLMETHANE IN THE PRESENCE OF AN N-ALKYL-4,4'-DIAMINODIPHENYLMETHANE | DEGUSSA AG (DE) | 2004-01-22 | — | — | WO | disclosed |
| EP-0001425-B1 | SUPPORTED RUTHENIUM CATALYST, PROCESS FOR ITS PREPARATION, AND ITS USE AS A HYDROGENATION CATALYST | BAYER AG (DE) | 1980-08-20 | — | — | EP | disclosed |
| US-4186145-A | Process for the hydrogenation of an aromatic amine and the supported ruthenium catalyst used in the process | BAYER AKTIENGESELLSCHAFT (DE) | 1980-01-29 | — | — | US | disclosed |
| EP-0001425-A1 | Supported ruthenium catalyst, process for its preparation, and its use as a hydrogenation catalyst | BAYER AG (DE) | 1979-04-18 | — | — | EP | disclosed |