Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INMT | O95050 | 6/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6184424 | 1.00 | INMT (0.75) | INMTUSP2ACHECYP1A2CYP2D6 | |
| Bicarbonate SCHEMBL6363121 | 0.91 | INMT (0.84) | INMTUSP2ACHECYP1A2CYP2D6 | |
| Bicarbonate SCHEMBL6184428 | 0.89 | INMT (0.81) | INMTUSP2ACHECYP1A2CYP2D6 | |
| Bicarbonate SCHEMBL6183133 | 0.89 | INMT (0.83) | INMTUSP2ACHECYP1A2CYP2D6 | |
| Fluoride Ion SCHEMBL6183829 | 0.87 | INMT (0.91) | INMTUSP2ACHESMN1; SMN2 | |
| SCHEMBL6853620 | 0.87 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2 | |
| SCHEMBL3047 | 0.87 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2 | |
| SCHEMBL2734323 | 0.87 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2 | |
| SCHEMBL2401189 | 0.87 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2 | |
| SCHEMBL17417853 | 0.87 | INMT (1.00) | INMTUSP2ACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397376-B1 | METHOD FOR PRODUCING PERBENZYLATED 1-O-GLYCOSIDES | SCHERING AG (DE) | 2005-05-04 | — | — | EP | claimed |