Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16865878 | 0.91 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL6423584 | 0.91 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL7099805 | 0.91 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL16865875 | 0.91 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL28103281 | 0.87 | ALDH1A1 (0.44) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL16865876 | 0.87 | ALDH1A1 (0.41) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL16649548 | 0.86 | MAPT (0.44) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL10361478 | 0.85 | ALDH1A1 (0.48) | ALDH1A1LMNAKDM4EMAPTGAA | |
| Hydrochloric Acid SCHEMBL5108645 | 0.83 | GAA (0.47) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL6693234 | 0.82 | PDE4A (0.50) | ALDH1A1LMNATNFSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105899508-B | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2017-07-04 | — | — | CN | disclosed |
| EP-2603215-A2 | NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE | Philadelphia Health and Education Corporation (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021629-A2 | NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2012-02-16 | — | — | WO | disclosed |