Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623386 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL28103052 | 0.85 | LMNA (0.40) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL2999171 | 0.81 | TP53 (0.47) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL13981506 | 0.81 | ACHE (0.47) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL28103261 | 0.81 | ACHE (0.47) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL10361478 | 0.80 | ALDH1A1 (0.48) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL2997838 | 0.80 | MAPT (0.50) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL2990146 | 0.80 | PDE4A (0.46) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL1827890 | 0.80 | PDE4A (0.46) | ALDH1A1LMNATNFKDM4EMAPT | |
| SCHEMBL7099805 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105899508-B | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-105899508-A | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2016-08-24 | — | — | CN | disclosed |