Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259663 | 0.88 | PDE5A (0.61) | GAAPDE5AALDH1A1KDM4EMAPT | |
| SCHEMBL6238376 | 0.86 | PDE5A (0.49) | GAAPDE5AALDH1A1KDM4EMAPT | |
| SCHEMBL6237808 | 0.86 | KMT2A (0.49) | GAAPDE5AALDH1A1KDM4EMAPT | |
| SCHEMBL6239210 | 0.80 | MAPT (0.47) | PDE5AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL7690215 | 0.77 | RPS6KB2 (0.60) | GAAPDE5AALDH1A1KDM4EMAPT | |
| SCHEMBL7695652 | 0.77 | RPS6KB2 (0.60) | PDE5AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6236522 | 0.77 | ABCG2 (0.48) | PDE5AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6237490 | 0.77 | ABCG2 (0.67) | PDE5AALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6235369 | 0.77 | MEN1 (0.58) | GAAPDE5AALDH1A1KDM4EMAPT | |
| SCHEMBL7696931 | 0.76 | RPS6KB2 (0.55) | GAAALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |