Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238376 | 0.85 | PDE5A (0.49) | ABCG2PDE5AMEN1KMT2ARPS6KB2 | |
| SCHEMBL6259663 | 0.85 | PDE5A (0.61) | ABCG2ABCB1PDE5AMEN1KMT2A | |
| SCHEMBL6237490 | 0.85 | ABCG2 (0.67) | ABCG2EGFRABCB1PDE5AMEN1 | |
| SCHEMBL6235369 | 0.85 | MEN1 (0.58) | ABCG2EGFRABCB1PDE5AMEN1 | |
| SCHEMBL6239609 | 0.81 | MAPT (0.51) | ABCG2EGFRABCB1PDE5AMEN1 | |
| SCHEMBL6239843 | 0.81 | ABCG2 (0.53) | ABCG2EGFRABCB1PDE5AMEN1 | |
| SCHEMBL7696175 | 0.81 | RPS6KB2 (0.56) | ABCG2EGFRABCB1PDE5AMEN1 | |
| SCHEMBL7695652 | 0.80 | RPS6KB2 (0.60) | ABCG2PDE5AMEN1KMT2ARPS6KB2 | |
| SCHEMBL7697772 | 0.79 | RPS6KB2 (0.58) | ABCG2ABCB1PDE5AMEN1KMT2A | |
| SCHEMBL7691382 | 0.78 | ABCG2 (0.61) | ABCG2EGFRABCB1PDE5AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |