Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 8/20 | 0.53 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238757 | 0.75 | RPS6KB2 (0.79) | RPS6KB2SRPK1KDM4EMEN1KMT2A | |
| SCHEMBL6234452 | 0.74 | KDM4E (0.54) | RPS6KB2SRPK1KDM4EDHFRMEN1 | |
| SCHEMBL2972148 | 0.70 | KDM4E (0.63) | KDM4EMEN1KMT2ARXFP1PRNP | |
| SCHEMBL6237157 | 0.70 | RPS6KB2 (0.54) | RPS6KB2SRPK1KDM4EDHFRALDH1A1 | |
| SCHEMBL31060401 | 0.70 | RPS6KB2 (1.00) | RPS6KB2SRPK1KDM4EMEN1KMT2A | |
| SCHEMBL16027135 | 0.69 | RPS6KB2 (0.74) | RPS6KB2SRPK1KDM4EDHFRMEN1 | |
| SCHEMBL31393470 | 0.69 | RPS6KB2 (0.74) | RPS6KB2SRPK1KDM4EDHFRMEN1 | |
| SCHEMBL21044590 | 0.68 | KDM4E (0.58) | RPS6KB2SRPK1KDM4EMEN1KMT2A | |
| SCHEMBL19066635 | 0.68 | RPS6KB2 (0.71) | RPS6KB2SRPK1KDM4EDHFRMEN1 | |
| SCHEMBL6233558 | 0.68 | RPS6KB2 (0.51) | RPS6KB2SRPK1KDM4EDHFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | claimed |
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |